Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963484 | 0.84 | L3MBTL1 (0.40) | RAB9AALDH1A1LMNATSHRSMN1; SMN2 | |
| SCHEMBL4929659 | 0.81 | ALDH1A1 (0.46) | ALDH1A1LMNATSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL16415410 | 0.78 | L3MBTL1 (0.40) | RAB9AALDH1A1LMNATSHRSMN1; SMN2 | |
| SCHEMBL960091 | 0.77 | GPR119 (0.43) | SMN1; SMN2USP2 | |
| SCHEMBL28865415 | 0.77 | POLB (0.58) | ALDH1A1LMNATSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL16235813 | 0.77 | EPHX2 (0.38) | ALDH1A1TSHRPOLBEPHX2USP2 | |
| SCHEMBL1770819 | 0.77 | EPHX2 (0.38) | ALDH1A1TSHRSMN1; SMN2L3MBTL1POLB | |
| SCHEMBL1667133 | 0.76 | L3MBTL1 (0.45) | ALDH1A1LMNASMN1; SMN2L3MBTL1POLB | |
| SCHEMBL5249800 | 0.74 | EPHX2 (0.43) | ALDH1A1LMNATSHRSMN1; SMN2EPHX2 | |
| SCHEMBL16416212 | 0.73 | POLB (0.42) | RAB9AALDH1A1LMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032582-A1 | PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007122410-A1 | PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-11-01 | — | — | WO | disclosed |