Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | HTR1A | P08908 | 5/20 | 0.70 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.70 |
| ▸ | HTR1D | P28221 | 4/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.70 |
| ▸ | HTR2B | P41595 | 3/20 | 0.70 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.70 |
| ▸ | HTR1B | P28222 | 3/20 | 0.70 |
| ▸ | HTR2A | P28223 | 3/20 | 0.70 |
| ▸ | HTR2C | P28335 | 3/20 | 0.70 |
| ▸ | HTR7 | P34969 | 3/20 | 0.70 |
| ▸ | HTR6 | P50406 | 3/20 | 0.70 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.70 |
| ▸ | HTR1E | P28566 | 2/20 | 0.70 |
| ▸ | HTR5A | P47898 | 2/20 | 0.70 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.70 |
| ▸ | HTR3B | O95264 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | HTR1F | P30939 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5085972 | 0.92 | KMT2A (0.65) | KMT2AHTR1AMTNR1AHTR1DCYP2D6 | |
| SCHEMBL5085568 | 0.92 | KMT2A (0.65) | KMT2AHTR1AMTNR1AHTR1DCYP2D6 | |
| SCHEMBL466333 | 0.89 | KMT2A (0.70) | KMT2AHTR1AMTNR1AHTR1DCYP2D6 | |
| SCHEMBL5144423 | 0.89 | KMT2A (0.74) | KMT2AHTR1AMTNR1AHTR1DCYP2D6 | |
| SCHEMBL5146979 | 0.88 | KMT2A (0.66) | KMT2AHTR1AMTNR1AHTR1DCYP2D6 | |
| SCHEMBL16058705 | 0.88 | KMT2A (0.69) | KMT2AHTR1AMTNR1AHTR1DCYP2D6 | |
| SCHEMBL28414663 | 0.88 | KMT2A (0.69) | KMT2AHTR1AMTNR1AHTR1DCYP2D6 | |
| SCHEMBL5227242 | 0.88 | KMT2A (0.69) | KMT2AHTR1AMTNR1AHTR1DCYP2D6 | |
| SCHEMBL3689658 | 0.87 | KMT2A (0.59) | KMT2AHTR1AMTNR1AHTR1DCYP2D6 | |
| SCHEMBL5144364 | 0.84 | KMT2A (0.65) | KMT2AHTR1AMTNR1AHTR1DCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851855-B9 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | MACEF (FR) | 2003-05-21 | — | — | EP | claimed |
| EP-0851855-B1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | MACEF (FR) | 2002-06-05 | — | — | EP | claimed |
| EP-0851855-A1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | CEMAF (FR) | 1998-07-08 | — | — | EP | claimed |
| WO-1997006140-A1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | CEMAF (FR) | 1997-02-20 | — | — | WO | claimed |
| EP-2083818-A2 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | University of Sunderland (GB) | 2009-08-05 | — | — | EP | disclosed |
| US-20090005430-A1 | Receptor Blocker and Vasodilator Comprising Indole Derivative as Active Ingredient | NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY (JP) | 2009-01-01 | — | — | US | disclosed |
| WO-2008062167-A2 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | UNIVERSITY OF SUNDERLAND (GB) | 2008-05-29 | — | — | WO | disclosed |
| WO-2007101863-A1 | THERAPEUTIC COMBINATION OF A 5HT2 RECEPTOR ANTAGONIST AND OF A 5HT2 RECEPTOR ACTIVATOR | MACEF (FR) | 2007-09-13 | — | — | WO | disclosed |
| WO-2007101863-A1 | THERAPEUTIC COMBINATION OF A 5HT2 RECEPTOR ANTAGONIST AND OF A 5HT2 RECEPTOR ACTIVATOR | MACEF (FR) | 2007-09-13 | — | — | WO | disclosed |
| EP-0851855-B9 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | MACEF (FR) | 2003-05-21 | — | — | EP | disclosed |
| EP-0851855-B1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | MACEF (FR) | 2002-06-05 | — | — | EP | disclosed |
| US-6140372-A | N-(2-(2-ACETYL-7-METHOXYNAPHTH-1-YL)ETHYL)ACETAMIDE; SEDATIVES; MELATONIN DISORDERS; DRUGS; COSMETICS; ANTIDEPRESSANTS; PSYCHIATRIC DISORDERS, E.G., STRESS, ANXIOLYTIC AGENTS, INSOMNIA, SCHIZOPHRENIA, PSYCHOSIS | CEMAF AND LABORATORIES BESINS ISOVESCO S.A. (FR) | 2000-10-31 | — | — | US | disclosed |
| US-6004991-A | COMPOUNDS FOR COSMETICS WITH ENANTIOMORPHS | CEMAF AND LABORATOIRES BESINS ISCOVESCO S.A. (FR) | 1999-12-21 | — | — | US | disclosed |
| EP-0851855-A1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | CEMAF (FR) | 1998-07-08 | — | — | EP | disclosed |
| WO-1997006140-A1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | CEMAF (FR) | 1997-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005430-A1 | Receptor Blocker and Vasodilator Comprising Indole Derivative as Active Ingredient | ADRB2, ADRB1, ADRA2B | KMT2A 1542/4885HTR1A 34/4885MTNR1A 261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.