Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258624 | 0.81 | KDM4E (1.00) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5566472 | 0.81 | KDM4E (1.00) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14122752 | 0.79 | ALDH1A1 (0.58) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2513921 | 0.77 | HSD17B10 (0.46) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1645664 | 0.75 | ALDH1A1 (0.44) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9435264 | 0.75 | CYP2A6 (0.54) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL17385581 | 0.75 | HSD17B10 (0.44) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5249435 | 0.75 | TSHR (0.54) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1644210 | 0.75 | HSD17B10 (0.44) | HSD17B10ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7304753 | 0.75 | HSD17B10 (0.59) | HSD17B10ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115340483-A | Naphthyl pyrrolindione compound, preparation method and application thereof | 南京吉星生物技术开发有限公司 | 2022-11-15 | — | — | CN | disclosed |
| US-7482339-B2 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2009-01-27 | — | — | US | disclosed |
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2006-12-14 | — | — | US | disclosed |
| EP-1659117-A1 | 2-NAPHTHYLIMINO-1,3-THIAZINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2006-05-24 | — | — | EP | disclosed |
| US-6846953-B1 | Aromatic amides | WARNER LAMBERT COMPANY (US) | 2005-01-25 | — | — | US | disclosed |
| EP-1178953-B1 | AROMATIC AMIDES | WARNER LAMBERT CO (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-1178953-A1 | AROMATIC AMIDES | WARNER-LAMBERT COMPANY (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000068184-A1 | AROMATIC AMIDES | WARNER-LAMBERT COMPANY (US) | 2000-11-16 | — | — | WO | disclosed |
| US-4731450-A | Process for perfluoroalkylation of aromatic derivatives | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1988-03-15 | — | — | US | disclosed |
| EP-0023584-B1 | PROCESS FOR THE PREPARATION OF TRIFLUOROMETHYL NAPHTHALENES | BAYER AG (DE) | 1983-01-26 | — | — | EP | disclosed |
| US-4331613-A | Process for the preparation of trifluoromethylnaphthalenes | BAYER AKTIENGESELLSCHAFT (DE) | 1982-05-25 | — | — | US | disclosed |
| EP-0023584-A1 | Process for the preparation of trifluoromethyl naphthalenes | BAYER AG (DE) | 1981-02-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | NPM1, OXTR, CYP2S1 | HSD17B10 1357/4885ALDH1A1 1571/4885KDM4E 4479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.