Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | KCNJ11 | Q14654 | 18/20 | 0.55 |
| ▸ | ABCC9 | O60706 | 10/20 | 0.55 |
| ▸ | ABCC8 | Q09428 | 10/20 | 0.55 |
| ▸ | KCNJ8 | Q15842 | 10/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258624 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| Acetamide SCHEMBL7260906 | 0.91 | KDM4E (0.82) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL7258623 | 0.87 | KDM4E (0.76) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL10036538 | 0.81 | KDM4E (0.69) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL4076480 | 0.81 | HSD17B10 (0.68) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL3885735 | 0.81 | KDM4E (0.68) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL2784215 | 0.81 | KDM4E (0.68) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL2784620 | 0.81 | MEN1 (0.67) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL14593291 | 0.80 | KDM4E (0.66) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL2782869 | 0.80 | KDM4E (0.67) | KDM4EMEN1MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089404-A1 | NAPHTHALENE AMIDES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2003-10-30 | — | — | WO | claimed |
| US-20030199578-A1 | Naphthalene amides as potassium channel openers | ABBOTT LABORATORIES | 2003-10-23 | — | — | US | claimed |
| US-20070166288-A1 | Formulation to improve survival of transplanted cells | UNIVERSITY OF WASHINGTON | 2007-07-19 | — | — | US | disclosed |
| WO-2003089404-A1 | NAPHTHALENE AMIDES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2003-10-30 | — | — | WO | disclosed |
| US-20030199578-A1 | Naphthalene amides as potassium channel openers | ABBOTT LABORATORIES | 2003-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199578-A1 | Naphthalene amides as potassium channel openers | KCNJ2, KCNN2, KCNJ1 | KDM4E 1005/4885MEN1 982/4885MAPT 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.