Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | CX3CR1 | P49238 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072400 | 0.96 | CCR2 (0.61) | CCR2SIGMAR1CX3CR1ALDH1A1KMT2A | |
| SCHEMBL249743 | 0.81 | CX3CR1 (0.44) | CCR2SIGMAR1CX3CR1ALDH1A1DRD2 | |
| SCHEMBL3177907 | 0.74 | KDM4E (0.48) | CCR2SIGMAR1CX3CR1ALDH1A1BACE1 | |
| SCHEMBL11576999 | 0.74 | SIGMAR1 (0.65) | CCR2SIGMAR1BACE1DRD2DRD4 | |
| SCHEMBL205373 | 0.74 | CCR2 (0.47) | CCR2SIGMAR1CX3CR1ALDH1A1DRD2 | |
| SCHEMBL4074069 | 0.73 | MEN1 (0.60) | ALDH1A1KMT2A | |
| SCHEMBL4844836 | 0.72 | CCR2 (0.71) | CCR2SIGMAR1DRD2DRD4 | |
| SCHEMBL4847367 | 0.72 | CCR2 (0.71) | CCR2SIGMAR1DRD2DRD4 | |
| SCHEMBL28741993 | 0.71 | SIGMAR1 (0.77) | SIGMAR1 | |
| SCHEMBL2445773 | 0.71 | CXCR4 (0.54) | SIGMAR1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745010-B1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | claimed |
| US-20070112007-A1 | Cyclohexyl-1, 4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-05-17 | — | — | US | claimed |
| US-20070112007-A1 | Cyclohexyl-1, 4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112007-A1 | Cyclohexyl-1, 4-diamine compounds | PKD1, DDC, DPYD | CCR2 2965/4885SIGMAR1 3262/4885CX3CR1 4296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.