Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.66 |
| ▸ | HTR2C | P28335 | 4/20 | 0.66 |
| ▸ | HTR2B | P41595 | 4/20 | 0.66 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | P4HB | P07237 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2700558 | 0.96 | HTR2A (0.66) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| SCHEMBL28843767 | 0.82 | HTR2A (0.50) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| SCHEMBL10487277 | 0.72 | DRD3 (0.56) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| SCHEMBL29591293 | 0.69 | MAOA (0.46) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| SCHEMBL4419988 | 0.69 | MAOA (0.46) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| SCHEMBL23944932 | 0.69 | PARP1 (0.46) | MAOAMAOBNOS3NOS1NOS2 | |
| SCHEMBL11065657 | 0.69 | HTR1D (0.51) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| SCHEMBL13983903 | 0.68 | HTR2C (0.66) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| SCHEMBL22174146 | 0.64 | HTR2A (0.44) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| SCHEMBL1278375 | 0.64 | BCL2L1 (0.52) | NOS3NOS1NOS2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083819-B1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORP (US) | 2017-02-22 | — | — | EP | disclosed |
| CN-101023055-B | Cyclic amine derivative or salt thereof | ASTELLAS PHARMA INC | 2010-10-06 | — | — | CN | disclosed |
| EP-1795524-A4 | CYCLIC AMINE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2009-08-05 | — | — | EP | disclosed |
| US-20070197594-A1 | Cyclic amine derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2007-08-23 | — | — | US | disclosed |
| US-20070197594-A1 | Cyclic amine derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2007-08-23 | — | — | US | disclosed |
| CN-101023055-A | Cyclic amine derivative or salt thereof | ASTELLAS PHARMA INC (JP) | 2007-08-22 | — | — | CN | disclosed |
| EP-1795524-A1 | CYCLIC AMINE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2007-06-13 | — | — | EP | disclosed |
| EP-1795524-A1 | CYCLIC AMINE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006033318-A1 | CYCLIC AMINE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197594-A1 | Cyclic amine derivative or salt thereof | GRIN1, PARK7, GRIN3A | HTR2A 575/4885HTR2C 913/4885HTR2B 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.