Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.56 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11065657 | 0.74 | HTR1D (0.51) | DRD3HTR1ACHRM2CHRM1CHRM3 | |
| SCHEMBL11065970 | 0.72 | HTR1A (1.00) | DRD3HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL2700558 | 0.72 | HTR2A (0.66) | DRD3HTR1ACHRM2CHRM1CHRM3 | |
| SCHEMBL4078348 | 0.72 | HTR2A (0.66) | DRD3HTR1ACHRM2CHRM1CHRM3 | |
| SCHEMBL10487258 | 0.68 | PLAU (0.41) | DRD3PLAUDRD2ADRA1AOPRK1 | |
| SCHEMBL9670992 | 0.68 | MAPT (0.50) | DRD3PLAUDRD2OPRK1 | |
| SCHEMBL9670719 | 0.68 | MAPT (0.50) | DRD3PLAUDRD2OPRK1 | |
| Hydrochloric Acid SCHEMBL10574257 | 0.67 | MAPT (0.49) | DRD3PLAUDRD2OPRK1 | |
| SCHEMBL10487293 | 0.66 | LMNA (0.44) | DRD3PLAUDRD2ADRA1AOPRK1 | |
| SCHEMBL28843767 | 0.63 | HTR2A (0.50) | DRD3HTR1ACHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4885373-A | AMINE DERVIVATIVES USED AS ANTIDEPRESSANT AND DOPAMINERGIC STIMULANTS | ADIR ET CIE (FR) | 1989-12-05 | — | — | US | disclosed |
| US-4874878-A | CHEMICAL INTERMEDIATES FOR ANTIDEPRESSANTS | ADIR ET CIE (FR) | 1989-10-17 | — | — | US | disclosed |
| US-4863951-A | ANTIDEPRESSANTS, ANTIAGRESSIVES, DOPAMINERGIC PROPERTIES | ADIR ET CIE (FR) | 1989-09-05 | — | — | US | disclosed |
| US-4851429-A | ANTIDEPRESSANT, TRANQUILIZERS | ADIR ET CIE (FR) | 1989-07-25 | — | — | US | disclosed |
| US-4470990-A | 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and their use as dopamine receptor stimulants | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-09-11 | — | — | US | disclosed |
| US-4470990-A | 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and their use as dopamine receptor stimulants | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-09-11 | — | — | US | disclosed |