Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 5/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | HTR2B | P41595 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487277 | 0.74 | DRD3 (0.56) | HTR1ADRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL4078348 | 0.69 | HTR2A (0.66) | HTR1ADRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL2700558 | 0.69 | HTR2A (0.66) | HTR1ADRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL7932835 | 0.69 | HTR7 (0.69) | HTR1DHTR1ACHRM2CHRM1CHRM3 | |
| SCHEMBL11072209 | 0.69 | HTR7 (0.69) | HTR1DHTR1ACHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL7926756 | 0.68 | HTR7 (0.67) | HTR1DHTR1ACHRM2CHRM1CHRM3 | |
| SCHEMBL14591377 | 0.67 | HTR1D (0.51) | HTR1DHTR1AHTR2CHTR2BHTR7 | |
| SCHEMBL7935409 | 0.67 | HTR1D (0.51) | HTR1DHTR1AHTR7GRIN2B | |
| SCHEMBL14591337 | 0.67 | HTR1D (0.51) | HTR1DHTR1AHTR2CHTR2BHTR7 | |
| SCHEMBL8677765 | 0.67 | SIGMAR1 (0.54) | HTR1DDRD3CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4470990-A | 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and their use as dopamine receptor stimulants | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-09-11 | — | — | US | disclosed |