Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.42 |
| ▸ | STK4 | Q13043 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.38 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075945 | 0.89 | OPRM1 (0.57) | OPRM1OPRD1OPRK1CCNT1EPHX2 | |
| SCHEMBL4083677 | 0.88 | OPRM1 (0.57) | OPRM1OPRD1OPRK1CSNK2A1EPHX2 | |
| SCHEMBL12608136 | 0.83 | OPRM1 (0.41) | OPRM1OPRD1OPRK1CSNK2A1SHMT1 | |
| Hydrochloric Acid SCHEMBL3340392 | 0.82 | OPRM1 (0.41) | OPRM1OPRD1OPRK1CSNK2A1SHMT1 | |
| SCHEMBL4071718 | 0.82 | MAP4K4 (0.41) | OPRM1OPRD1OPRK1CSNK2A1CCNT1 | |
| SCHEMBL4080420 | 0.80 | OPRM1 (0.45) | OPRM1OPRD1OPRK1EPHX2CHRM2 | |
| SCHEMBL4483783 | 0.80 | OPRM1 (0.56) | OPRM1OPRD1OPRK1CHRM2CHRM1 | |
| SCHEMBL4081761 | 0.80 | OPRM1 (0.46) | OPRM1OPRD1OPRK1EPHX2CHRM2 | |
| SCHEMBL1348506 | 0.79 | OPRM1 (0.42) | OPRM1OPRD1OPRK1LRRK2SHMT1 | |
| SCHEMBL1348140 | 0.79 | FAAH (0.45) | OPRM1OPRD1OPRK1EPHX2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |