Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075945 | 0.93 | OPRM1 (0.57) | OPRM1OPRD1OPRK1MAPK1CCR2 | |
| SCHEMBL4081821 | 0.91 | OPRM1 (0.48) | OPRM1OPRD1OPRK1CHEK2SLC6A2 | |
| SCHEMBL4078358 | 0.88 | OPRM1 (0.51) | OPRM1OPRD1OPRK1EPHX2CHRM2 | |
| SCHEMBL4481852 | 0.88 | OPRM1 (0.57) | OPRM1OPRD1OPRK1MAPK1CHEK2 | |
| SCHEMBL4080420 | 0.85 | OPRM1 (0.45) | OPRM1OPRD1OPRK1MAPK1EPHX2 | |
| SCHEMBL4081761 | 0.85 | OPRM1 (0.46) | OPRM1OPRD1OPRK1CCR2EPHX2 | |
| SCHEMBL4483783 | 0.81 | OPRM1 (0.56) | OPRM1OPRD1OPRK1MAPK1CHRM2 | |
| SCHEMBL4071701 | 0.80 | OPRM1 (0.47) | OPRM1OPRD1OPRK1ADRB1ADRB3 | |
| SCHEMBL12608136 | 0.79 | OPRM1 (0.41) | OPRM1OPRD1OPRK1CSNK2A1 | |
| Hydrochloric Acid SCHEMBL3340392 | 0.78 | OPRM1 (0.41) | OPRM1OPRD1OPRK1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |