Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.35 |
| ▸ | TPH1 | P17752 | 1/20 | 0.35 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76480 | 0.72 | ALDH1A1 (0.39) | LMNAHSD11B1DDB1CRBNNOX4 | |
| SCHEMBL14123133 | 0.68 | GRIN1 (0.53) | TLR7GRIN1GRIN2BDDB1CRBN | |
| SCHEMBL2170191 | 0.65 | HSD11B1 (0.41) | LMNAHSD11B1DDB1CRBNMEN1 | |
| SCHEMBL5827636 | 0.64 | TLR7 (0.49) | TLR7GRIN1GRIN2BLMNADDB1 | |
| SCHEMBL30615329 | 0.64 | LMNA (0.56) | GRIN1GRIN2BLMNAMEN1ALDH1A1 | |
| SCHEMBL4293641 | 0.64 | LMNA (0.56) | GRIN1GRIN2BLMNAMEN1ALDH1A1 | |
| SCHEMBL8592487 | 0.63 | TLR7 (0.51) | TLR7GRIN1GRIN2BTPH1TPH2 | |
| SCHEMBL6087851 | 0.62 | GRIN1 (0.45) | TLR7GRIN1GRIN2BNOX4TPH1 | |
| SCHEMBL77108 | 0.62 | ALDH1A1 (0.40) | LMNAHSD11B1DDB1CRBNMEN1 | |
| SCHEMBL6982033 | 0.62 | ALDH1A1 (0.64) | MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | claimed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | claimed |
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |