Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089181 | 0.82 | — | — | |
| SCHEMBL4088882 | 0.82 | — | — | |
| SCHEMBL4079042 | 0.73 | ESR1 (0.39) | ESR1CYP2C9ESR2HSD11B1HSD11B2 | |
| SCHEMBL4084173 | 0.60 | — | — | |
| SCHEMBL4556735 | 0.59 | P2RX7 (0.55) | ESR1CYP2C9ESR2HSD11B1HSD11B2 | |
| Toluene SCHEMBL19873397 | 0.58 | P2RX7 (0.46) | ESR1CYP2C9ESR2 | |
| SCHEMBL1161107 | 0.57 | ESR1 (0.50) | ESR1CYP2C9ESR2HSD11B1HSD11B2 | |
| SCHEMBL19618075 | 0.57 | ESR1 (0.50) | ESR1CYP2C9ESR2HSD11B1HSD11B2 | |
| SCHEMBL236361 | 0.56 | GRIN2D (0.52) | ESR1CYP2C9ESR2 | |
| SCHEMBL25797411 | 0.56 | GRIN2D (0.52) | ESR1CYP2C9ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | claimed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | claimed |