Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.53 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19808553 | 0.87 | P2RX7 (0.50) | P2RX7HSD11B1HSD11B2KMT2AFAAH | |
| SCHEMBL3773962 | 0.86 | NPC1 (0.54) | P2RX7HSD11B1HSD11B2KMT2AFAAH | |
| SCHEMBL1675970 | 0.82 | HSD11B1 (0.57) | HSD11B1KMT2AFAAHEPHX2 | |
| SCHEMBL16530082 | 0.82 | HSD11B1 (0.57) | HSD11B1KMT2AFAAHEPHX2 | |
| SCHEMBL13018717 | 0.81 | HSD11B1 (0.44) | P2RX7HSD11B1HSD11B2 | |
| SCHEMBL9948611 | 0.79 | HSD11B1 (0.49) | HSD11B1HSD11B2ESR1CYP2C9ESR2 | |
| SCHEMBL1675682 | 0.78 | KMT2A (0.74) | HSD11B1KMT2AFAAHEPHX2 | |
| SCHEMBL3773939 | 0.77 | HSD11B1 (0.45) | P2RX7HSD11B1HSD11B2KMT2AFAAH | |
| SCHEMBL2024608 | 0.77 | NR1H4 (0.47) | HSD11B1HSD11B2KMT2AFAAH | |
| SCHEMBL3781481 | 0.76 | FAAH (0.43) | P2RX7HSD11B1HSD11B2KMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129652-A2 | N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE | High Point Pharmaceuticals, LLC (US) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008101907-A2 | N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE | HIGH POINT PHARMACEUTICALS, LLC (GB) | 2008-08-28 | — | — | WO | disclosed |