Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5307775 | 0.94 | THRB (0.49) | THRBATML3MBTL1RAB9AHSD11B1 | |
| SCHEMBL5308786 | 0.83 | THRB (0.62) | THRBATML3MBTL1RAB9AHSD11B1 | |
| SCHEMBL14011496 | 0.81 | RAB9A (0.50) | THRBATML3MBTL1RAB9AHSD11B1 | |
| SCHEMBL3718960 | 0.81 | RAB9A (0.52) | THRBATML3MBTL1RAB9AHSD11B1 | |
| SCHEMBL4074760 | 0.79 | RAB9A (0.51) | THRBATML3MBTL1RAB9AHSD11B1 | |
| SCHEMBL12233216 | 0.79 | RAB9A (0.51) | THRBATML3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL5407237 | 0.79 | MEN1 (0.52) | THRBATML3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL704010 | 0.78 | RAB9A (0.51) | THRBATML3MBTL1RAB9AHSD11B1 | |
| SCHEMBL1487944 | 0.78 | THRB (0.68) | THRBATML3MBTL1GAAKDM4E | |
| SCHEMBL3768429 | 0.78 | KMT2A (0.55) | THRBATML3MBTL1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796793-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1796793-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029154-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-16 | — | — | WO | disclosed |