Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | RORB | Q92753 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8174124 | 0.87 | TSHR (0.56) | TSHRP2RX4NR4A1NR4A2NR4A3 | |
| SCHEMBL9189728 | 0.82 | MEN1 (0.59) | ALOX5RORCRORBNR4A1NR4A2 | |
| SCHEMBL9195598 | 0.78 | KEAP1 (0.56) | ALOX5TSHRRORCRORBNR4A1 | |
| SCHEMBL23759473 | 0.76 | NR4A1 (0.52) | ALOX5TSHRRORCRORBAKR1C3 | |
| SCHEMBL1420869 | 0.76 | CDC25B (0.58) | ALOX5RORCRORBNR4A1NR4A2 | |
| SCHEMBL1641502 | 0.74 | NR4A1 (0.70) | NR4A1NR4A2NR4A3KDM4EALDH1A1 | |
| SCHEMBL28690577 | 0.74 | AKR1C3 (0.59) | ALOX5AKR1C3AKR1C2NR4A1NR4A2 | |
| SCHEMBL30892682 | 0.73 | BCAT2 (0.55) | ALOX5TSHRRORCRORBNR4A1 | |
| SCHEMBL4032874 | 0.73 | NR4A1 (0.52) | ALOX5RORCRORBNR4A1NR4A2 | |
| SCHEMBL31621277 | 0.73 | BCAT2 (0.55) | ALOX5TSHRRORCRORBNR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2006278-B2 | BENZOFLUORENE COMPOUND AND USE THEREOF | TOSOH CORP (JP) | 2016-10-12 | — | — | EP | disclosed |
| US-8993805-B2 | Benzofluorene compound and use thereof | TOSOH CORPORATION (JP) | 2015-03-31 | — | — | US | disclosed |
| US-8993805-B2 | Benzofluorene compound and use thereof | TOSOH CORPORATION (JP) | 2015-03-31 | — | — | US | disclosed |
| US-8993805-B2 | Benzofluorene compound and use thereof | TOSOH CORPORATION (JP) | 2015-03-31 | — | — | US | disclosed |
| EP-2006278-B1 | BENZOFLUORENE COMPOUND AND USE THEREOF | TOSOH CORP (JP) | 2012-12-26 | — | — | EP | disclosed |
| EP-2006278-A9 | BENZOFLUORENE COMPOUND AND USE THEREOF | Tosoh Corporation (JP) | 2009-08-05 | — | — | EP | disclosed |
| EP-2006278-A9 | BENZOFLUORENE COMPOUND AND USE THEREOF | Tosoh Corporation (JP) | 2009-08-05 | — | — | EP | disclosed |
| US-20090184312-A1 | BENZOFLUORENE COMPOUND AND USE THEREOF | TOSOH CORPORATION (JP) | 2009-07-23 | — | — | US | disclosed |
| US-20090184312-A1 | BENZOFLUORENE COMPOUND AND USE THEREOF | TOSOH CORPORATION (JP) | 2009-07-23 | — | — | US | disclosed |
| US-20090184312-A1 | BENZOFLUORENE COMPOUND AND USE THEREOF | TOSOH CORPORATION (JP) | 2009-07-23 | — | — | US | disclosed |
| EP-2006278-A2 | BENZOFLUORENE COMPOUND AND USE THEREOF | Tosoh Corporation (JP) | 2008-12-24 | — | — | EP | disclosed |
| EP-2006278-A2 | BENZOFLUORENE COMPOUND AND USE THEREOF | Tosoh Corporation (JP) | 2008-12-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090184312-A1 | BENZOFLUORENE COMPOUND AND USE THEREOF | SLC7A1, SLC43A1, SLC7A5 | ALOX5 2520/4885TSHR 3118/4885P2RX4 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.