Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.57 |
| ▸ | GSK3A | P49840 | 6/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 3/20 | 0.52 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | TLK1 | Q9UKI8 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7132790 | 0.87 | PTGS2 (0.44) | GSK3BGSK3AADORA2AADORA1BRDT | |
| SCHEMBL3820556 | 0.85 | GSK3B (0.52) | GSK3BGSK3AADORA2AADORA1BRDT | |
| SCHEMBL3819171 | 0.83 | GSK3B (0.51) | GSK3BGSK3AADORA2AADORA1BRDT | |
| SCHEMBL30999908 | 0.82 | GSK3B (0.55) | GSK3BGSK3AADORA2AADORA1BRDT | |
| SCHEMBL3729848 | 0.82 | CAMK2D (0.44) | GSK3BPGRCLK4 | |
| SCHEMBL934146 | 0.82 | GSK3B (0.65) | GSK3BGSK3AADORA2AADORA1BRDT | |
| SCHEMBL3820693 | 0.81 | GSK3B (0.63) | GSK3BGSK3AADORA2AADORA1BRDT | |
| SCHEMBL28785378 | 0.79 | GSK3B (0.54) | GSK3BGSK3ASTK10SLKTDP2 | |
| SCHEMBL30999976 | 0.79 | GSK3B (0.59) | GSK3BGSK3AADORA2AADORA1BRDT | |
| SCHEMBL3818590 | 0.78 | GSK3B (0.51) | GSK3BGSK3AADORA2AADORA1BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874298-A4 | METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1-ARYL-3-AZABICYCLO[3,1,0]HEXANES | DOV PHARMACEUTICAL INC (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1874298-A2 | METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1-ARYL-3-AZABICYCLO[3,1,0]HEXANES | DOV Pharmaceutical Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006096810-A2 | METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1-ARYL-3-AZABICYCLO[3.1.0] HEXANES | DOV PHARMACEUTICAL, INC. (US) | 2006-09-14 | — | — | WO | disclosed |
| EP-0267574-A2 | Heat resistant copolymer composition | Sumitomo Dow Limited (JP) | 1988-05-18 | — | — | EP | disclosed |