Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072013 | 0.79 | KAT6A (0.45) | KAT6AHDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL14572884 | 0.67 | KDM2B (0.48) | KAT6AHDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL4072726 | 0.67 | TYR (0.53) | — | |
| SCHEMBL4078410 | 0.66 | HSD11B1 (0.50) | — | |
| SCHEMBL4073629 | 0.65 | MMP2 (0.50) | CYP3A4 | |
| SCHEMBL2376992 | 0.64 | SLC40A1 (0.45) | KAT6AHDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL10157186 | 0.64 | NR1H2 (0.47) | KAT6AHDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL4071235 | 0.64 | ALDH1A1 (0.42) | KAT6AHDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL4071237 | 0.64 | ALDH1A1 (0.42) | KAT6AHDAC8HDAC3HDAC4HDAC1 | |
| SCHEMBL4070014 | 0.64 | ALDH1A1 (0.42) | KAT6AHDAC8HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625112-B1 | NOVEL COMPOUNDS FOR TREATMENT OF OBESITY | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-07-22 | — | — | EP | disclosed |