Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084189 | 0.91 | HRH3 (0.40) | HPGDHRH3OPRM1OPRL1 | |
| SCHEMBL4081016 | 0.88 | EPHX2 (0.45) | HPGDOPRM1OPRL1SIGMAR1GAA | |
| SCHEMBL207560 | 0.88 | POLB (0.41) | LMNAPOLBHPGDAVPR1AGAA | |
| SCHEMBL206987 | 0.86 | POLB (0.56) | LMNAPOLBHPGDOPRM1OPRL1 | |
| SCHEMBL209932 | 0.85 | AVPR1A (0.44) | LMNAAVPR1AOXTR | |
| SCHEMBL206809 | 0.85 | KMT2A (0.46) | LMNAOPRM1OPRL1SIGMAR1GAA | |
| SCHEMBL208694 | 0.84 | AVPR1A (0.41) | LMNAPOLBHPGDAVPR1AGAA | |
| SCHEMBL205873 | 0.84 | UTS2R (0.43) | LMNAPOLBHPGDOPRM1OPRL1 | |
| SCHEMBL4056032 | 0.80 | CCR2 (0.46) | LMNAOPRM1OPRL1SIGMAR1MAPT | |
| SCHEMBL4076358 | 0.80 | AVPR1A (0.43) | AVPR1AOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745010-B1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | claimed |