Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 8/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.56 |
| ▸ | ABL1 | P00519 | 11/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | PRKCA | P17252 | 3/20 | 0.53 |
| ▸ | BCR | P11274 | 6/20 | 0.48 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087392 | 0.92 | PDGFRB (0.54) | PDGFRAPDGFRBABL1HDAC1HDAC3 | |
| SCHEMBL4086274 | 0.84 | PDGFRB (0.67) | PDGFRAPDGFRBABL1HDAC1HDAC3 | |
| SCHEMBL4089975 | 0.82 | ABL1 (0.79) | PDGFRAPDGFRBABL1HDAC1HDAC3 | |
| SCHEMBL4077534 | 0.79 | ABL1 (0.64) | PDGFRAPDGFRBABL1HDAC1HDAC3 | |
| SCHEMBL4084979 | 0.76 | PDGFRB (0.82) | PDGFRAPDGFRBABL1HDAC1HDAC3 | |
| SCHEMBL4087636 | 0.74 | ABL1 (0.61) | PDGFRAPDGFRBABL1HDAC1HDAC3 | |
| SCHEMBL4382247 | 0.73 | PDGFRB (0.71) | PDGFRAPDGFRBABL1EGFRPRKCA | |
| SCHEMBL7474316 | 0.73 | HDAC1 (0.68) | PDGFRAPDGFRBABL1HDAC1EGFR | |
| SCHEMBL4087589 | 0.72 | ABL1 (0.75) | PDGFRAPDGFRBABL1HDAC1EGFR | |
| SCHEMBL4080335 | 0.70 | PRKCA (0.78) | PDGFRAPDGFRBABL1EGFRPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2060565-A1 | Novel bifunctional compounds which inhibit protein kinases and histone deacetylases | 4SC AG (DE) | 2009-05-20 | — | — | EP | disclosed |