Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.75 |
| ▸ | BCR | P11274 | 12/20 | 0.75 |
| ▸ | EGFR | P00533 | 3/20 | 0.67 |
| ▸ | SRC | P12931 | 3/20 | 0.67 |
| ▸ | PRKACA | P17612 | 1/20 | 0.67 |
| ▸ | PRKACG | P22612 | 1/20 | 0.67 |
| ▸ | PRKACB | P22694 | 1/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.63 |
| ▸ | PRKCA | P17252 | 6/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.60 |
| ▸ | ABL2 | P42684 | 1/20 | 0.55 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | PRKCB | P05771 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | PRKCH | P24723 | 1/20 | 0.51 |
| ▸ | PRKCI | P41743 | 1/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29366999 | 0.86 | ABL1 (1.00) | ABL1BCREGFRSRCPRKACA | |
| SCHEMBL2392 | 0.86 | ABL1 (1.00) | ABL1BCREGFRSRCPRKACA | |
| SCHEMBL29555505 | 0.86 | ABL1 (1.00) | ABL1BCREGFRSRCPRKACA | |
| Ammonia Solution, Strong SCHEMBL4749564 | 0.85 | ABL1 (0.98) | ABL1BCREGFRSRCPRKACA | |
| Hydrochloric Acid SCHEMBL2419016 | 0.85 | ABL1 (0.98) | ABL1BCREGFRSRCPRKACA | |
| SCHEMBL4080335 | 0.84 | PRKCA (0.78) | ABL1BCREGFRSRCPRKACA | |
| SCHEMBL3860532 | 0.83 | ABL1 (0.83) | ABL1BCREGFRSRCPRKACA | |
| SCHEMBL4382247 | 0.83 | PDGFRB (0.71) | ABL1BCREGFRSRCPDGFRB | |
| SCHEMBL3869178 | 0.83 | ABL1 (0.74) | ABL1BCREGFRSRCPRKACA | |
| SCHEMBL3051320 | 0.83 | ABL1 (0.71) | ABL1BCREGFRSRCPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065734-A1 | NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES | 4SC AG (DE) | 2011-03-17 | — | — | US | disclosed |
| EP-2060565-A1 | Novel bifunctional compounds which inhibit protein kinases and histone deacetylases | 4SC AG (DE) | 2009-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065734-A1 | NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES | HDAC1, HDAC11, MAP2K2 | ABL1 783/4885BCR 862/4885EGFR 1304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.