Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.71 |
| ▸ | IL1RN | P18510 | 1/20 | 0.71 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | DHFR | P00374 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332569 | 0.93 | TSHR (0.70) | KEAP1IL1RNERAP1ALDH1A1KMT2A | |
| SCHEMBL25031372 | 0.84 | KEAP1 (1.00) | KEAP1IL1RNERAP1ALDH1A1KMT2A | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL114765 | 0.84 | KEAP1 (1.00) | KEAP1IL1RNERAP1ALDH1A1KMT2A | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL27503772 | 0.82 | KEAP1 (0.95) | KEAP1IL1RNERAP1ALDH1A1KMT2A | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL11513007 | 0.82 | KEAP1 (0.95) | KEAP1IL1RNERAP1ALDH1A1KMT2A | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL6399560 | 0.82 | KEAP1 (0.95) | KEAP1IL1RNERAP1ALDH1A1KMT2A | |
| SCHEMBL31681365 | 0.82 | AURKA (0.67) | ALDH1A1KMT2AMEN1AURKADHFR | |
| SCHEMBL9001182 | 0.81 | KMT2A (1.00) | KEAP1IL1RNERAP1ALDH1A1KMT2A | |
| SCHEMBL810795 | 0.80 | KMT2A (0.91) | KEAP1IL1RNERAP1ALDH1A1KMT2A | |
| SCHEMBL18424409 | 0.79 | KEAP1 (0.73) | KEAP1IL1RNERAP1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054392-A2 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA | Boehringer Ingelheim International GmbH (DE) | 2009-05-06 | — | — | EP | disclosed |
| WO-2007146981-A2 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-21 | — | — | WO | disclosed |