Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.91 |
| ▸ | MEN1 | O00255 | 4/20 | 0.91 |
| ▸ | PKM | P14618 | 2/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.91 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.91 |
| ▸ | IL1RN | P18510 | 1/20 | 0.91 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.91 |
| ▸ | CA12 | O43570 | 2/20 | 0.77 |
| ▸ | CA1 | P00915 | 2/20 | 0.77 |
| ▸ | CA2 | P00918 | 2/20 | 0.77 |
| ▸ | CA9 | Q16790 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | PGR | P06401 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | HTR6 | P50406 | 1/20 | 0.67 |
| ▸ | UQCRB | P14927 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9001182 | 0.95 | KMT2A (1.00) | KMT2AMEN1PKMALDH1A1KEAP1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL114765 | 0.95 | KEAP1 (1.00) | KMT2AMEN1PKMALDH1A1KEAP1 | |
| SCHEMBL25031372 | 0.95 | KEAP1 (1.00) | KMT2AMEN1PKMALDH1A1KEAP1 | |
| SCHEMBL13167612 | 0.93 | KMT2A (0.80) | KMT2AMEN1PKMALDH1A1KEAP1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL11513007 | 0.93 | KEAP1 (0.95) | KMT2AMEN1PKMALDH1A1KEAP1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL6399560 | 0.93 | KEAP1 (0.95) | KMT2AMEN1PKMALDH1A1KEAP1 | |
| SCHEMBL3686387 | 0.91 | KMT2A (0.84) | KMT2AMEN1PKMALDH1A1KEAP1 | |
| SCHEMBL523562 | 0.91 | KMT2A (0.77) | KMT2AMEN1PKMALDH1A1KEAP1 | |
| SCHEMBL9001183 | 0.91 | KMT2A (0.84) | KMT2AMEN1PKMALDH1A1KEAP1 | |
| Lithium SCHEMBL31041155 | 0.91 | KMT2A (0.77) | KMT2AMEN1PKMALDH1A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146548-A1 | AMIDE, ARYL SULFONAMIDE, ARYL UREA, AND a,b-DIKETONE DERIVED CARBOXYLESTERASE INHIBITORS, AND THEIR METHODS OF USE | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2008-06-19 | — | — | US | claimed |
| US-20050054691-A1 | Carboxylesterase inhibitors | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2005-03-10 | — | — | US | claimed |
| WO-2005021721-A2 | CARBOXYLESTERASE INHIBITORS | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2005-03-10 | — | — | WO | claimed |
| US-5264474-A | Plasticizing thermoplastic or thermosetting resins with sulfonamide compounds | MTM AMERICAS INC. (US) | 1993-11-23 | — | — | US | claimed |
| US-4981890-A | POLYHALOAROMATIC AND AROMATIC BIS-SULFONAMIDE | ETHYL CORPORATION (US) | 1991-01-01 | — | — | US | claimed |
| US-4957958-A | IMPROVED MELT FLOW | ETHYL CORPORATION (US) | 1990-09-18 | — | — | US | claimed |
| US-20230288610-A1 | WAVELENGTH SELECTIVE ABSORPTION FILTER AND DISPLAY DEVICE | FUJIFILM CORPORATION (JP) | 2023-09-14 | — | — | US | disclosed |
| EP-2998359-B1 | METHOD FOR IMPROVING THE ELECTRICAL-INSULATING PROPERTY AND THE FOGGING RESISTANCE OF A POLYESTER RESIN COMPOSITION | ADEKA CORP (JP) | 2019-08-21 | — | — | EP | disclosed |
| US-9726932-B2 | Optical film, optical compensation film, polarizing plate and liquid crystal display | FUJIFILM CORPORATION (JP) | 2017-08-08 | — | — | US | disclosed |
| US-9726932-B2 | Optical film, optical compensation film, polarizing plate and liquid crystal display | FUJIFILM CORPORATION (JP) | 2017-08-08 | — | — | US | disclosed |
| EP-2484725-B1 | POLYESTER RESIN COMPOSITION, POLYESTER FIBER, POLYESTER RESIN MOLDED ARTICLE, AND PROCESS FOR PRODUCTION OF NUCLEATING AGENT FOR POLYESTER RESIN | ADEKA CORP (JP) | 2017-07-19 | — | — | EP | disclosed |
| EP-2407514-B1 | REINFORCED POLYESTER RESIN COMPOSITION | ADEKA CORP (JP) | 2017-03-01 | — | — | EP | disclosed |
| US-9563075-B2 | Method for manufacturing liquid crystal display device provided with front plate, and liquid crystal display device provided with front plate | Konica Minolta, Inc. (JP) | 2017-02-07 | — | — | US | disclosed |
| WO-1999041756-A1 | INTRINSICALLY CONDUCTIVE POLYMER BLENDS HAVING A LOW PERCOLATION THRESHOLD | ZIPPERLING KESSLER & CO. (GMBH & CO.) (DE) | 1999-08-19 | — | — | WO | disclosed |
| WO-1999019391-A1 | INTRINSICALLY CONDUCTIVE POLYMER/PLASTICIZER BLENDS WITH ENHANCED CONDUCTIVITY | ZIPPERLING KESSLER & CO. (GMBH & CO.) (DE) | 1999-04-22 | — | — | WO | disclosed |
| US-5871671-A | Intrinsically conductive polymer/plasticizer blends with enhanced conductivity | MONSANTO COMPANY (US) | 1999-02-16 | — | — | US | disclosed |
| US-5468868-A | Process for the selective chlorination of 4,5-dihydro-1-phenyl-1H-1,2,4-triazol-5-one | FMC CORPORATION (US) | 1995-11-21 | — | — | US | disclosed |
| US-5264474-A | Plasticizing thermoplastic or thermosetting resins with sulfonamide compounds | MTM AMERICAS INC. (US) | 1993-11-23 | — | — | US | disclosed |
| US-4981890-A | POLYHALOAROMATIC AND AROMATIC BIS-SULFONAMIDE | ETHYL CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |
| US-4957958-A | IMPROVED MELT FLOW | ETHYL CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054691-A1 | Carboxylesterase inhibitors | CES1, CES2, BCHE | KMT2A 1241/4885MEN1 4615/4885PKM 705/4885 |
| US-20080146548-A1 | AMIDE, ARYL SULFONAMIDE, ARYL UREA, AND a,b-DIKETONE DERIVED CARBOXYLESTERASE INHIBITORS, AND THEIR METHODS OF USE | CES1, BCHE, CES2 | KMT2A 943/4885MEN1 4755/4885PKM 586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.