Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12831721 | 0.79 | CRHR1 (0.37) | CSNK1ECLK1CLK2CLK3GSK3B | |
| SCHEMBL4082939 | 0.79 | TSHR (0.39) | TSHRMAPTMAPK1ALDH1A1KDM4E | |
| SCHEMBL30349372 | 0.77 | ACACB (0.39) | CSNK1ECLK1CLK2CLK3GSK3B | |
| SCHEMBL25157447 | 0.77 | ACACB (0.39) | CSNK1ECLK1CLK2CLK3GSK3B | |
| SCHEMBL16318466 | 0.74 | CRHR1 (0.42) | ALDH1A1KMT2ACRHR1HSD17B10LMNA | |
| SCHEMBL13885373 | 0.72 | GSK3B (0.32) | CSNK1ECLK1CLK2CLK3GSK3B | |
| SCHEMBL2854775 | 0.71 | HSD17B10 (0.57) | GSK3BTSHRMAPTMAPK1CASP1 | |
| SCHEMBL4099644 | 0.70 | ALDH1A1 (0.33) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27211979 | 0.67 | GRM2 (0.37) | TDP1ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL11901668 | 0.67 | PRMT5 (0.38) | TSHRMAPTTDP1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |