Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081070 | 0.79 | CSNK1E (0.36) | TSHRMAPK1ALDH1A1LMNAKMT2A | |
| SCHEMBL4091067 | 0.78 | TSHR (0.37) | TSHRMAPK1POLBALDH1A1LMNA | |
| SCHEMBL4566262 | 0.75 | TSHR (0.35) | TSHRMAPK1POLBALDH1A1LMNA | |
| SCHEMBL7721500 | 0.73 | POLB (0.63) | TSHRMAPK1POLBALDH1A1LMNA | |
| SCHEMBL16318466 | 0.71 | CRHR1 (0.42) | POLBALDH1A1LMNAKMT2ACRHR1 | |
| SCHEMBL4725224 | 0.68 | RAB9A (0.41) | MAPK1POLBALDH1A1LMNAMEN1 | |
| SCHEMBL17994849 | 0.68 | TP53 (0.35) | TSHRMAPK1POLBALDH1A1MEN1 | |
| SCHEMBL31411154 | 0.67 | TLR7 (0.63) | POLBLMNAKCNH2 | |
| SCHEMBL31439915 | 0.66 | PDE10A (0.41) | TSHRPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL31122306 | 0.65 | GRM2 (0.39) | MAPK1MEN1KMT2AGRM2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |