Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | TAS2R46 | P59540 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | TERT | O14746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13629611 | 1.00 | MEN1 (0.55) | MEN1KMT2APKMTAS2R46TDP1 | |
| SCHEMBL4081155 | 1.00 | MEN1 (0.55) | MEN1KMT2APKMTAS2R46TDP1 | |
| SCHEMBL4755810 | 0.83 | PKM (0.61) | MEN1KMT2APKMTAS2R46TDP1 | |
| SCHEMBL13629605 | 0.83 | PKM (0.61) | MEN1KMT2APKMTAS2R46TDP1 | |
| SCHEMBL4092222 | 0.81 | PKM (0.68) | MEN1KMT2APKMTAS2R46TDP1 | |
| SCHEMBL13629604 | 0.81 | PKM (0.68) | MEN1KMT2APKMTAS2R46TDP1 | |
| SCHEMBL4092225 | 0.81 | PKM (0.68) | MEN1KMT2APKMTAS2R46TDP1 | |
| SCHEMBL13629612 | 0.81 | PKM (0.59) | MEN1KMT2APKMTAS2R46TDP1 | |
| SCHEMBL4092476 | 0.81 | PKM (0.59) | MEN1KMT2APKMTAS2R46TDP1 | |
| SCHEMBL4086305 | 0.78 | PKM (0.73) | MEN1KMT2APKMTAS2R46TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622465-B2 | Costunolide derivatives | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2009-11-24 | — | — | US | disclosed |
| US-20090131427-A1 | Costunolide Derivatives | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2009-05-21 | — | — | US | disclosed |
| US-7488836-B2 | Costunolide derivatives | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2009-02-10 | — | — | US | disclosed |
| US-20080051396-A1 | COSTUNOLIDE DERIVATIVES | HUTCHISON MEDIPHARMA LIMITED (BS) | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131427-A1 | Costunolide Derivatives | NOS1, NFKBIA, NOS2 | MEN1 1603/4885KMT2A 3988/4885PKM 4351/4885 |
| US-20080051396-A1 | COSTUNOLIDE DERIVATIVES | NOS1, NFKBIA, RELA | MEN1 1427/4885KMT2A 3142/4885PKM 3601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.