Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072010 | 1.00 | TSHR (0.38) | TSHRHTR2AHTR2CHTR2BPABPC1 | |
| SCHEMBL4069876 | 0.83 | ABL1 (0.40) | TSHRL3MBTL1TDP1ALDH1A1MEN1 | |
| SCHEMBL10359314 | 0.81 | HTR2B (0.42) | TSHRHTR2AHTR2CHTR2BPABPC1 | |
| SCHEMBL4080507 | 0.80 | USP2 (0.43) | TP53ALDH1A1CYP3A4MEN1KMT2A | |
| SCHEMBL4071169 | 0.78 | ALOX15 (0.44) | TSHRHTR2AHTR2CHTR2BL3MBTL1 | |
| SCHEMBL8280908 | 0.77 | FFAR4 (0.43) | TSHRHTR2AHTR2CHTR2BPABPC1 | |
| SCHEMBL3466564 | 0.77 | ACHE (0.43) | TSHRHTR2AHTR2CHTR2BPABPC1 | |
| SCHEMBL4072440 | 0.76 | MAPT (0.35) | ALDH1A1GAAMAPT | |
| SCHEMBL9032996 | 0.73 | ACHE (0.40) | TSHRHTR2AHTR2CHTR2BPABPC1 | |
| SCHEMBL17816443 | 0.73 | ACHE (0.40) | TSHRHTR2AHTR2CHTR2BPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |