Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081365 | 0.83 | TSHR (0.38) | TDP1L3MBTL1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4072010 | 0.83 | TSHR (0.38) | TDP1L3MBTL1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4078217 | 0.82 | PKM (0.43) | L3MBTL1HPGDMAPTSMN1; SMN2NPC1 | |
| SCHEMBL16956140 | 0.78 | CYP1A2 (0.46) | ABL1RIN1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4080507 | 0.78 | USP2 (0.43) | HPGDMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4073503 | 0.77 | ADRA2A (0.42) | SMN1; SMN2KDM4EALDH1A1GAATSHR | |
| SCHEMBL12635306 | 0.75 | CYP1A2 (0.44) | ABL1RIN1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL17404115 | 0.74 | CYP1A2 (0.46) | ABL1RIN1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL21574039 | 0.74 | CYP1A2 (0.46) | ABL1RIN1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16952605 | 0.73 | ALDH1A1 (0.47) | ABL1RIN1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |