Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Thiopental. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.73 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.73 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.73 |
| ▸ | MMP9 | P14780 | 2/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiopental SCHEMBL1611312 | 1.00 | LMNA (1.00) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Thiopental SCHEMBL6688973 | 0.98 | LMNA (0.96) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Thiopental SCHEMBL28832536 | 0.91 | LMNA (0.82) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL24966 | 0.85 | CYP3A4 (1.00) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| SCHEMBL120258 | 0.85 | LMNA (0.73) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL735353 | 0.85 | CYP3A4 (1.00) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| SCHEMBL120257 | 0.85 | LMNA (0.73) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL2376470 | 0.85 | CYP3A4 (1.00) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL1256614 | 0.83 | CYP3A4 (0.96) | LMNACYP3A4KDM4EALDH1A1GABRB3 | |
| Pentobarbital SCHEMBL26057 | 0.83 | CYP3A4 (0.96) | LMNACYP3A4KDM4EALDH1A1GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 11028 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-20260041939-A1 | METHODS FOR THE TREATMENT OF HYPERTENSION VIA TRANSCRANIAL-FOCUSED-ULTRASOUND | SUNNYBROOK RES INST (CA) | 2026-02-12 | — | — | US | claimed |
| US-20250235641-A1 | DEVICE TO DELIVER A PREDETERMINED AMOUNT OF A SUBSTANCE TO A NATURAL ORIFICE OF THE BODY | APTARGROUP INC. (US) | 2025-07-24 | — | — | US | claimed |
| EP-3441087-B1 | METHODS OF TREATING CHRONIC PAIN | TEVA PHARMACEUTICALS INT GMBH (CH) | 2025-02-19 | — | — | EP | claimed |
| EP-4426308-A1 | METHODS OF TREATING RESPIRATORY DEPRESSION MODULATED BY A NON-OPIOID AGENT | Enalare Therapeutics Inc. (US) | 2024-09-11 | — | — | EP | claimed |
| EP-3863708-B1 | MIXED IONIC CONDUCTORS AND CORRESPONDING DEVICES, SYSTEMS AND METHODS OF MAKING | BATTELLE MEMORIAL INSTITUTE (US) | 2024-09-11 | — | — | EP | claimed |
| WO-2023055939-A9 | APPARATUS, SYSTEMS AND METHODS FOR TRANSDERMAL DRUG DELIVERY, PERMEABILITY ENHANCEMENT AND AUGMENTATION | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2024-04-25 | — | — | WO | claimed |
| US-20240099995-A1 | METHOD OF PREPARING A TOPICAL PHARMACEUTICAL COMPOSITION | PHEBRA PTY LTD (AU) | 2024-03-28 | — | — | US | claimed |
| EP-3189834-B1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | HAISCO INNOVATIVE PHARMACEUTICAL PTE LTD (SG) | 2024-01-17 | — | — | EP | claimed |
| EP-4291171-A1 | METHOD OF PREPARING A TOPICAL PHARMACEUTICAL COMPOSITION | Phebra Pty Ltd (AU) | 2023-12-20 | — | — | EP | claimed |
| EP-0038541-B1 | NOVEL PRODRUGS OF BIOLOGICALLY ACTIVE AGENTS CONTAINING MERCAPTO GROUPS, PROCESS FOR PREPARING AND THERAPEUTICALLY EFFECTIVE COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1986-08-13 | — | — | EP | claimed |
| EP-0036742-B1 | PERIOPERATIVE APPLICATION OF ELECTRONIC PAIN CONTROL IN COMBINATION WITH ANESTHETIC AGENTS | CODMAN & SHURTLEFF INC. (US) | 1986-07-16 | — | — | EP | claimed |
| EP-0168522-A2 | Active agent-containing shaped article | Akzo Patente GmbH (DE) | 1986-01-22 | — | — | EP | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| US-4533346-A | System for automatic feedback-controlled administration of drugs | PHARMACONTROL CORPORATION (US) | 1985-08-06 | — | — | US | claimed |
| EP-0038541-A1 | Novel prodrugs of biologically active agents containing mercapto groups, process for preparing and therapeutically effective composition containing the same | MERCK & CO. INC. (US) | 1981-10-28 | — | — | EP | claimed |
| US-4280494-A | System for automatic feedback-controlled administration of drugs | COSGROVE ROBERT J JUN | 1981-07-28 | — | — | US | claimed |
| US-4244939-A | RADIOIMMUNOASSAY | BAXTER TRAVENOL LABORATORIES, INC. (US) | 1981-01-13 | — | — | US | claimed |
| US-4168308-A | Composition for enhancing the administration of pharmacologically active agents | APOTEKSVARUCENTRALEN VITRUM AB (SE) | 1979-09-18 | — | — | US | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |