Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SCN1A | P35498 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072447 | 0.79 | MRGPRX4 (0.35) | SCN5A | |
| SCHEMBL70690 | 0.72 | ACHE (0.42) | MEN1KMT2ALMNATSHR | |
| SCHEMBL4079547 | 0.72 | SCN5A (0.37) | SCN5ACYP2D6KMT2ASCN4ALMNA | |
| SCHEMBL4081365 | 0.71 | TSHR (0.38) | MEN1KMT2ACYP3A4TSHRHTR2A | |
| SCHEMBL4072010 | 0.71 | TSHR (0.38) | MEN1KMT2ACYP3A4TSHRHTR2A | |
| SCHEMBL6256715 | 0.70 | KMT2A (0.53) | ADRA2AKMT2AMAPK1LMNACYP1A2 | |
| SCHEMBL4071169 | 0.70 | ALOX15 (0.44) | CYP2D6MEN1KMT2AMAPK1BLM | |
| SCHEMBL768033 | 0.69 | TSHR (0.55) | SCN5AMEN1KMT2ASCN4ALMNA | |
| SCHEMBL768032 | 0.69 | TSHR (0.55) | SCN5AMEN1KMT2ASCN4ALMNA | |
| SCHEMBL27398663 | 0.67 | CSNK2A1 (0.34) | SCN5ACYP2D6SCN4ALMNASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |