Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4074968 | 0.93 | OPRM1 (0.60) | OPRM1OPRD1OPRK1RARBHDAC1 | |
| SCHEMBL4487434 | 0.90 | SMN1; SMN2 (0.50) | OPRM1OPRD1OPRK1RARBHDAC1 | |
| SCHEMBL4498120 | 0.83 | HDAC1 (0.53) | OPRM1OPRD1OPRK1HDAC1HDAC8 | |
| SCHEMBL1347689 | 0.81 | HDAC1 (0.61) | OPRM1OPRD1OPRK1HDAC1HDAC8 | |
| SCHEMBL4073644 | 0.81 | OPRM1 (0.53) | OPRM1OPRD1OPRK1RARBHDAC1 | |
| SCHEMBL1347863 | 0.80 | OPRM1 (0.52) | OPRM1OPRD1OPRK1HDAC1ADRB1 | |
| Hydrochloric Acid SCHEMBL4073979 | 0.80 | OPRM1 (0.52) | OPRM1OPRD1OPRK1RARBHDAC1 | |
| SCHEMBL4486859 | 0.79 | OPRM1 (0.52) | OPRM1OPRD1OPRK1 | |
| SCHEMBL4071701 | 0.79 | OPRM1 (0.47) | OPRM1OPRD1OPRK1RARBADRB1 | |
| SCHEMBL4074391 | 0.79 | HDAC1 (0.56) | HDAC1ADRB1ADRB3ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |