Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487434 | 0.88 | SMN1; SMN2 (0.50) | OPRM1OPRD1OPRK1PPARA | |
| SCHEMBL4074391 | 0.86 | HDAC1 (0.56) | PARP1ROCK2GPR52 | |
| SCHEMBL4073993 | 0.83 | SCN3A (0.42) | MAOBPARP10CHEK2 | |
| SCHEMBL1788221 | 0.82 | OPRM1 (0.54) | OPRM1OPRD1OPRK1MAOBPARP10 | |
| SCHEMBL4074968 | 0.81 | OPRM1 (0.60) | OPRM1OPRD1OPRK1 | |
| SCHEMBL4081861 | 0.79 | OPRM1 (0.53) | OPRM1OPRD1OPRK1 | |
| SCHEMBL4073644 | 0.77 | OPRM1 (0.53) | OPRM1OPRD1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL3340260 | 0.76 | SRC (0.50) | OPRM1OPRD1OPRK1PARP1SRC | |
| Hydrochloric Acid SCHEMBL4073979 | 0.76 | OPRM1 (0.52) | OPRM1OPRD1OPRK1 | |
| SCHEMBL4075498 | 0.76 | OPRM1 (0.43) | OPRM1OPRD1OPRK1ROCK2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |