Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4074968 | 0.92 | OPRM1 (0.60) | OPRM1OPRD1OPRK1RARBHDAC1 | |
| SCHEMBL4081861 | 0.90 | OPRM1 (0.53) | SMN1; SMN2HDAC8HDAC6OPRM1OPRD1 | |
| SCHEMBL4074391 | 0.88 | HDAC1 (0.56) | HDAC1ADRB1ADRB3PPARGALDH1A1 | |
| SCHEMBL4486859 | 0.88 | OPRM1 (0.52) | OPRM1OPRD1OPRK1PPARA | |
| SCHEMBL4073993 | 0.87 | SCN3A (0.42) | SMN1; SMN2RARBHDAC1ALDH1A1HPGD | |
| SCHEMBL4498120 | 0.85 | HDAC1 (0.53) | SMN1; SMN2HDAC8HDAC6OPRM1OPRD1 | |
| SCHEMBL4075498 | 0.84 | OPRM1 (0.43) | HDAC6OPRM1OPRD1OPRK1RARB | |
| SCHEMBL2026285 | 0.83 | ESR2 (0.55) | RARBPPARGPPARAALDH1A1HPGD | |
| SCHEMBL4073644 | 0.83 | OPRM1 (0.53) | SMN1; SMN2OPRM1OPRD1OPRK1RARB | |
| Hydrochloric Acid SCHEMBL4073979 | 0.82 | OPRM1 (0.52) | SMN1; SMN2OPRM1OPRD1OPRK1RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |