Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080566 | 0.82 | ALOX15 (0.41) | MAPTKMT2AALOX15ALDH1A1KDM4E | |
| SCHEMBL768676 | 0.80 | ALOX15 (0.43) | MAPTKMT2AALOX15SLC1A3SLC1A2 | |
| SCHEMBL768677 | 0.80 | ALOX15 (0.43) | MAPTKMT2AALOX15SLC1A3SLC1A2 | |
| SCHEMBL19607313 | 0.79 | ADRB3 (0.38) | MAPTKMT2AALOX15ALDH1A1KDM4E | |
| SCHEMBL4075604 | 0.71 | MEN1 (0.48) | KMT2AALOX15ALDH1A1CYP1A2 | |
| SCHEMBL4076693 | 0.69 | ALOX15 (0.43) | KMT2AALOX15ALDH1A1KDM4EADRB2 | |
| SCHEMBL4078535 | 0.69 | ADRB1 (0.46) | KMT2AALOX15KDM4EADRB2ADRB1 | |
| SCHEMBL5987276 | 0.67 | LMNA (0.30) | LMNA | |
| SCHEMBL12634713 | 0.66 | SLC6A4 (0.40) | ALDH1A1LMNAHTR2ASLC6A4 | |
| SCHEMBL17499050 | 0.65 | KDM4E (0.59) | MAPTKMT2AALOX15ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |