SCHEMBL4082589

SCHEMBL4082589

ClC[Si](Cl)(CCc1ccccc1)CCc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.46
ALDH1A1 P00352 2/20 0.42
HPGD P15428 1/20 0.42
ALOX15 P16050 1/20 0.42
ALOX12 P18054 1/20 0.42
CASP1 P29466 1/20 0.42
HSD17B10 Q99714 1/20 0.42
MAOA P21397 4/20 0.41
MAOB P27338 4/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
KDM1A O60341 1/20 0.41
LMNA P02545 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
HTR1A P08908 1/20 0.41
ADRA2A P08913 1/20 0.41
CYP2C8 P10632 1/20 0.41
CYP2D6 P10635 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1482295 0.88 TDP1 (0.52) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL4086275 0.82 TDP1 (0.46) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL4077822 0.80 TDP1 (0.50) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL4079914 0.80 ALDH1A1 (0.52) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL1030793 0.78 TDP1 (0.52) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL208903 0.78 TDP1 (0.52) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL6532094 0.76 TDP1 (0.50) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL6036792 0.76 TDP1 (0.44) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL8423094 0.74 TDP1 (0.48) TDP1ALDH1A1HPGDALOX15ALOX12
SCHEMBL523595 0.74 TDP1 (0.48) TDP1ALDH1A1HPGDALOX15ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1705207-B1 METHOD FOR PRODUCING POLYMER, POLYMER, COMPOSITION FOR FORMING INSULATING FILM, METHOD FOR PRODUCING INSULATING FILM, AND INSULATING FILM JSR CORP (JP) 2012-10-24 EP disclosed
US-7528207-B2 Method for producing polymer, polymer, composition for forming insulating film, method for producing insulating film, and insulating film JSR CORPORATION (JP) 2009-05-05 US disclosed
US-20070021580-A1 Method for producing polymer, polymer, composition for forming insulating film, method for producing insulating film, and insulating film JSR CORPORATION (JP) 2007-01-25 US disclosed
US-20070015892-A1 Method for producing polymer, polymer, composition for forming insulating film, method for producing insulating film, and insulating film JSR CORPORATION (JP) 2007-01-18 US disclosed
EP-1705206-A1 METHOD FOR PRODUCING POLYMER, POLYMER, COMPOSITION FOR FORMING INSULATING FILM, METHOD FOR PRODUCING INSULATING FILM, AND INSULATING FILM JSR Corporation (JP) 2006-09-27 EP disclosed
EP-1705207-A1 METHOD FOR PRODUCING POLYMER, POLYMER, COMPOSITION FOR FORMING INSULATING FILM, METHOD FOR PRODUCING INSULATING FILM, AND INSULATING FILM JSR Corporation (JP) 2006-09-27 EP disclosed