Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091067 | 0.82 | TSHR (0.37) | TSHRMAPK1POLBALDH1A1LMNA | |
| SCHEMBL13885373 | 0.82 | GSK3B (0.32) | TSHRMAPK1ALDH1A1LMNACRHR1 | |
| SCHEMBL4566261 | 0.79 | POLB (0.33) | TSHRMAPK1POLBMEN1KMT2A | |
| SCHEMBL4082939 | 0.75 | TSHR (0.39) | TSHRMAPK1POLBALDH1A1LMNA | |
| SCHEMBL4092944 | 0.68 | HTR2A (0.33) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7721500 | 0.67 | POLB (0.63) | TSHRMAPK1POLBALDH1A1LMNA | |
| SCHEMBL19135928 | 0.64 | PIK3CD (0.39) | MAPK1POLBALDH1A1CRHR1MEN1 | |
| SCHEMBL4095370 | 0.62 | CYP1A2 (0.41) | TSHRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4085111 | 0.61 | IMPDH2 (0.35) | TSHR | |
| SCHEMBL31411154 | 0.61 | TLR7 (0.63) | POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |