Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.79 |
| ▸ | POLB | P06746 | 8/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.79 |
| ▸ | NPC1 | O15118 | 4/20 | 0.79 |
| ▸ | RAB9A | P51151 | 4/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.72 |
| ▸ | HPGD | P15428 | 7/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | PPARG | P37231 | 2/20 | 0.69 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.69 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.69 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.69 |
| ▸ | UTRN | P46939 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2244809 | 0.91 | NPC1 (0.85) | ALDH1A1KDM4EPOLBSMN1; SMN2NPC1 | |
| SCHEMBL2243174 | 0.88 | NPC1 (1.00) | ALDH1A1KDM4EPOLBSMN1; SMN2NPC1 | |
| SCHEMBL13182114 | 0.86 | ALDH1A1 (0.69) | ALDH1A1KDM4EPOLBSMN1; SMN2NPC1 | |
| SCHEMBL2244953 | 0.85 | NPC1 (0.72) | ALDH1A1KDM4EPOLBSMN1; SMN2NPC1 | |
| SCHEMBL23034137 | 0.84 | NPC1 (0.67) | ALDH1A1KDM4EPOLBSMN1; SMN2NPC1 | |
| SCHEMBL23012175 | 0.84 | NPC1 (0.70) | ALDH1A1KDM4EPOLBSMN1; SMN2NPC1 | |
| SCHEMBL29479597 | 0.84 | NPC1 (0.70) | ALDH1A1KDM4EPOLBSMN1; SMN2NPC1 | |
| SCHEMBL2244509 | 0.84 | MAPT (0.79) | ALDH1A1KDM4EPOLBSMN1; SMN2NPC1 | |
| SCHEMBL16942520 | 0.83 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL29479738 | 0.83 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240287036-A1 | COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER | Argonaut Therapeutics Limited (GB) | 2024-08-29 | — | — | US | disclosed |
| EP-4352048-A1 | COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER | Argonaut Therapeutics Limited (GB) | 2024-04-17 | — | — | EP | disclosed |
| CN-117480162-A | Compounds for the treatment or prophylaxis of PRMT5 mediated diseases | 阿古诺治疗有限公司 | 2024-01-30 | — | — | CN | disclosed |
| WO-2022258986-A1 | COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER | Argonaut Therapeutics Limited (GB) | 2022-12-15 | — | — | WO | disclosed |
| US-20090203697-A1 | HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-08-13 | — | — | US | disclosed |
| CN-101448797-A | Heterocyclic type cinnamamide derivative | EISAI R&D MAN CO LTD (JP) | 2009-06-03 | — | — | CN | disclosed |
| EP-2019094-A1 | HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2009-01-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287036-A1 | COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER | PRMT5, PRMT6, PRMT1 | ALDH1A1 3909/4885KDM4E 818/4885POLB 768/4885 |
| US-20090203697-A1 | HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE | CLIC4, NR3C2, MAN2B1 | ALDH1A1 159/4885KDM4E 3267/4885POLB 4776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.