Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088677 | 0.94 | HDAC3 (0.66) | HDAC1HDAC2HDAC3KMT2AMEN1 | |
| SCHEMBL27294525 | 0.85 | KMT2A (0.72) | KMT2AMEN1PLAUHPGDPKM | |
| SCHEMBL3335404 | 0.83 | HDAC1 (0.84) | HDAC1HDAC2HDAC3KMT2AMEN1 | |
| SCHEMBL28592805 | 0.78 | CYP2C19 (0.64) | HDAC1HDAC2HDAC3KMT2AMEN1 | |
| SCHEMBL12819959 | 0.77 | MEN1 (0.62) | HDAC1HDAC2HDAC3KMT2AMEN1 | |
| SCHEMBL13642228 | 0.77 | HDAC1 (0.60) | HDAC1HDAC2HDAC3KMT2AHPGD | |
| SCHEMBL3118143 | 0.76 | ALDH1A1 (0.48) | HDAC1HDAC2HDAC3KMT2AMEN1 | |
| SCHEMBL4223097 | 0.75 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HPGDALDH1A1 | |
| SCHEMBL3334201 | 0.74 | HDAC1 (0.67) | HDAC1HDAC2HDAC3KMT2ARAB9A | |
| SCHEMBL4094232 | 0.72 | HDAC1 (0.72) | HDAC1HDAC2HDAC3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203692-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203692-A1 | NOVEL CHEMICAL COMPOUNDS | HIPK3, HIPK1, HIPK4 | HDAC1 1549/4885HDAC2 2038/4885HDAC3 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.