Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GAPDH | P04406 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913843 | 0.92 | KMT2A (0.48) | SMN1; SMN2MAPK1KMT2AMEN1NPC1 | |
| SCHEMBL13850061 | 0.83 | AURKA (0.46) | SMN1; SMN2MAPK1KMT2AMEN1NPC1 | |
| SCHEMBL4088328 | 0.83 | MAPK1 (0.41) | SMN1; SMN2MAPK1KMT2AMEN1NPC1 | |
| SCHEMBL4083540 | 0.83 | FGFR1 (0.50) | MAPK1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL4086290 | 0.81 | MAPT (0.40) | SMN1; SMN2MAPK1KMT2AMEN1NPC1 | |
| SCHEMBL4092150 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2MAPK1KMT2AMEN1NPC1 | |
| SCHEMBL4088272 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2MAPK1ALDH1A1MAPTLMNA | |
| SCHEMBL4082088 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPK1KMT2AMEN1NPC1 | |
| SCHEMBL4083197 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPK1KMT2AMEN1NPC1 | |
| SCHEMBL4086374 | 0.80 | HPGD (0.43) | SMN1; SMN2MAPK1KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |