Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 10/20 | 0.41 |
| ▸ | RAB9A | P51151 | 10/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 9/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089305 | 0.86 | NPC1 (0.42) | HPGDLMNANPC1RAB9AKMT2A | |
| SCHEMBL4078670 | 0.83 | AURKA (0.44) | HPGDLMNANPC1RAB9AKMT2A | |
| SCHEMBL4092896 | 0.81 | HDAC6 (0.51) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4083484 | 0.80 | SMN1; SMN2 (0.51) | HPGDLMNANPC1RAB9AKMT2A | |
| SCHEMBL4083540 | 0.79 | FGFR1 (0.50) | NPC1RAB9AKMT2AMEN1MAPK1 | |
| SCHEMBL1179801 | 0.78 | CDK7 (0.41) | KDM4EMAPK1 | |
| SCHEMBL4088652 | 0.78 | JAK2 (0.49) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4078387 | 0.78 | MAPK1 (0.48) | LMNANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4088272 | 0.78 | ALDH1A1 (0.40) | LMNASMN1; SMN2ALDH1A1NPSR1MAPK1 | |
| SCHEMBL4087457 | 0.76 | KLK7 (0.47) | HPGDLMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |