Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAPDH | P04406 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13850061 | 0.88 | AURKA (0.46) | MAPTALDH1A1SMN1; SMN2MAPK1TRPA1 | |
| SCHEMBL4086381 | 0.84 | FLT3 (0.42) | SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL651489 | 0.82 | RXFP1 (0.47) | MAPTALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL4082088 | 0.81 | SMN1; SMN2 (0.41) | MAPTALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL4083197 | 0.81 | SMN1; SMN2 (0.41) | MAPTALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL4083484 | 0.81 | SMN1; SMN2 (0.51) | MAPTALDH1A1SMN1; SMN2MAPK1TRPA1 | |
| SCHEMBL4083272 | 0.80 | APLNR (0.47) | MAPTALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL4088416 | 0.80 | LMNA (0.42) | MAPTSMN1; SMN2MAPK1KMT2AMEN1 | |
| SCHEMBL4088635 | 0.80 | AURKA (0.58) | — | |
| SCHEMBL740053 | 0.79 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2MAPK1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |