Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL295299 | 0.80 | ALDH1A1 (0.45) | ALDH1A1TSHRHPGDHSD17B10CYP3A4 | |
| SCHEMBL4074888 | 0.78 | TSHR (0.48) | ALDH1A1TSHRHPGDHSD17B10CYP3A4 | |
| SCHEMBL28566833 | 0.77 | ALDH1A1 (0.42) | ALDH1A1TSHRHPGDHSD17B10CYP3A4 | |
| SCHEMBL31036112 | 0.76 | PTPN1 (0.41) | ALDH1A1TSHRHPGDHSD17B10KDM4E | |
| SCHEMBL7670971 | 0.76 | PTPN1 (0.41) | ALDH1A1TSHRHPGDHSD17B10KDM4E | |
| SCHEMBL7306047 | 0.76 | PTPN1 (0.45) | ALDH1A1TSHRHPGDHSD17B10KDM4E | |
| SCHEMBL7306054 | 0.76 | PTPN1 (0.67) | ALDH1A1TSHRKDM4EMAPTPTPN1 | |
| SCHEMBL5656993 | 0.74 | CYP1A2 (0.49) | CYP3A4KDM4EBACE1KIF11POLB | |
| SCHEMBL30218963 | 0.74 | CYP1A2 (0.49) | CYP3A4KDM4EBACE1KIF11POLB | |
| SCHEMBL5383334 | 0.74 | HPRT1 (0.54) | ALDH1A1TSHRHPGDHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482339-B2 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2009-01-27 | — | — | US | disclosed |
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2006-12-14 | — | — | US | disclosed |
| EP-1659117-A1 | 2-NAPHTHYLIMINO-1,3-THIAZINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2006-05-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | NPM1, OXTR, CYP2S1 | ALDH1A1 1571/4885TSHR 440/4885HPGD 580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.