Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30218963 | 1.00 | CYP1A2 (0.49) | CYP1A2LMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23301079 | 0.81 | KIF11 (0.45) | CYP1A2KIF11CHUKTRPV1KDM4E | |
| SCHEMBL29656790 | 0.81 | KIF11 (0.45) | CYP1A2KIF11CHUKTRPV1KDM4E | |
| SCHEMBL28489057 | 0.79 | KIF11 (0.44) | CYP1A2KIF11CHUKIMPDH2TRPV1 | |
| SCHEMBL5659114 | 0.78 | LMNA (0.55) | CYP1A2LMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4083639 | 0.74 | ALDH1A1 (0.45) | CYP3A4KIF11KDM4EPOLBHTT | |
| SCHEMBL5656944 | 0.73 | IMPDH2 (0.55) | CYP1A2LMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25625876 | 0.72 | KIF11 (0.55) | KIF11CHUKTRPV1CDK5CDK5R1 | |
| SCHEMBL11365506 | 0.72 | LATS1 (0.47) | CYP1A2KIF11CHUKTDO2 | |
| SCHEMBL3326564 | 0.71 | PRKCH (0.55) | CYP1A2LMNACYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112457245-B | Synthesis method of 7- (trifluoromethyl) isoquinoline-5-amine | 苏州康润医药有限公司 | 2022-11-22 | — | — | CN | claimed |
| CN-112457245-A | Synthesis method of 7- (trifluoromethyl) isoquinoline-5-amine | 苏州康润医药有限公司 | 2021-03-09 | — | — | CN | claimed |
| CN-112457245-B | Synthesis method of 7- (trifluoromethyl) isoquinoline-5-amine | 苏州康润医药有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-112457245-B | Synthesis method of 7- (trifluoromethyl) isoquinoline-5-amine | 苏州康润医药有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-112457245-B | Synthesis method of 7- (trifluoromethyl) isoquinoline-5-amine | 苏州康润医药有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-112457245-A | Synthesis method of 7- (trifluoromethyl) isoquinoline-5-amine | 苏州康润医药有限公司 | 2021-03-09 | — | — | CN | disclosed |
| CN-112457245-A | Synthesis method of 7- (trifluoromethyl) isoquinoline-5-amine | 苏州康润医药有限公司 | 2021-03-09 | — | — | CN | disclosed |
| CN-112457245-A | Synthesis method of 7- (trifluoromethyl) isoquinoline-5-amine | 苏州康润医药有限公司 | 2021-03-09 | — | — | CN | disclosed |
| US-7285563-B2 | Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2007-10-23 | — | — | US | disclosed |
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | ARRB1, OPRL1, CNR1 | CYP1A2 464/4885LMNA 2921/4885CYP3A4 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.