Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828649 | 0.84 | KMT2A (0.53) | ALDH1A1GRM5RAB9AHTTSRD5A2 | |
| SCHEMBL10796499 | 0.83 | CNR2 (0.55) | ALDH1A1GRM5SRD5A2HPGDCES2 | |
| SCHEMBL1873600 | 0.83 | HSD17B14 (0.49) | ALDH1A1GRM5HTTHPGDCES2 | |
| SCHEMBL9827481 | 0.82 | KMT2A (0.56) | ALDH1A1LMNARAB9AHTTMAPT | |
| SCHEMBL960010 | 0.81 | ALDH1A1 (0.51) | ALDH1A1LMNAGRM5MAPTHPGD | |
| Toluene SCHEMBL28081324 | 0.80 | AKR1C3 (0.47) | ALDH1A1LMNARAB9AHTTSRD5A2 | |
| SCHEMBL10366443 | 0.79 | ALDH1A1 (0.50) | ALDH1A1LMNARAB9AHTTSRD5A2 | |
| SCHEMBL13932169 | 0.79 | KDM4E (0.50) | ALDH1A1GRM5MAPTHPGDPTGS1 | |
| SCHEMBL9828051 | 0.79 | SRD5A2 (0.49) | ALDH1A1LMNARAB9ASRD5A2MAPT | |
| SCHEMBL23564314 | 0.76 | PARP1 (0.50) | ALDH1A1GRM5RAB9AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742707-A4 | TREATMENT OF CNS DISORDERS USING CNS TARGET MODULATORS | HYPNION INC (US) | 2009-08-05 | — | — | EP | disclosed |
| US-7355042-B2 | Treatment of CNS disorders using CNS target modulators | HYPNION, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7355042-B2 | Treatment of CNS disorders using CNS target modulators | HYPNION, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7355042-B2 | Treatment of CNS disorders using CNS target modulators | HYPNION, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| EP-1443929-A4 | TREATMENT OF CNS DISORDERS USING CNS TARGET MODULATORS | HYPNION INC (US) | 2008-02-06 | — | — | EP | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-0249950-B1 | AROMATIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-06-19 | — | — | EP | disclosed |
| EP-0133534-B1 | PYRIDYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-10-10 | — | — | EP | disclosed |
| EP-0085959-B1 | AROMATIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-04-19 | — | — | EP | disclosed |
| EP-0249950-A1 | Aromatic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1987-12-23 | — | — | EP | disclosed |
| US-4657918-A | FREE FROM SEDATIVE EFFECTS | BURROUGHS WELLCOME CO. (US) | 1987-04-14 | — | — | US | disclosed |
| US-4650807-A | Antihistaminic compositions and methods containing pyridine derivatives | BURROUGHS WELLCOME CO. (US) | 1987-03-17 | — | — | US | disclosed |
| US-4562258-A | 6-[3-Amino-1-(4-tolyl)prop-1E-enyl]pyridine-2-carboxylic acid derivatives having antihistaminic activity | BURROUGHS WELLCOME CO. | 1985-12-31 | — | — | US | disclosed |
| EP-0133534-A2 | Pyridyl compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-02-27 | — | — | EP | disclosed |
| US-4501893-A | ANTIHISTAMINE/CANT CONTAINS CARBOXYL GROUPS | MEDEVA CALIFORNIA, INC. | 1985-02-26 | — | — | US | disclosed |
| EP-0085959-A2 | Aromatic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-08-17 | — | — | EP | disclosed |