SCHEMBL4083683

SCHEMBL4083683

COc1ccc(C(=O)N[C@H]2C[C@H](C)CC[C@H]2C(C)C)cc1OC

nearest known ligand 0.74

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 10/20 0.67
TRPM8 Q7Z2W7 1/20 0.64
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
TAS1R3 Q7RTX0 1/20 0.48
TAS1R1 Q7RTX1 1/20 0.48
PDE4A P27815 1/20 0.47
PDE4B Q07343 1/20 0.47
PDE4C Q08493 1/20 0.47
PDE4D Q08499 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4078851 1.00 TRPV1 (0.67) TRPV1TRPM8CYP2D6CYP2C9TAS1R3
SCHEMBL4088532 0.87 TRPV1 (0.61) TRPV1TRPM8
SCHEMBL4305683 0.87 TRPV1 (0.61) TRPV1TRPM8
SCHEMBL4311591 0.85 TRPV1 (0.76) TRPV1TRPM8
SCHEMBL11886341 0.84 TRPV1 (0.74) TRPV1TRPM8
SCHEMBL4088451 0.84 TRPV1 (0.74) TRPV1TRPM8
SCHEMBL11886519 0.84 TRPV1 (0.74) TRPV1TRPM8
SCHEMBL11886340 0.84 TRPV1 (0.74) TRPV1TRPM8
SCHEMBL4078842 0.82 TRPV1 (0.64) TRPV1
SCHEMBL4088516 0.82 TRPV1 (0.64) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8871288-B2 Aromatic neomenthylamides as flavoring substances SYMRISE AG (DE) 2014-10-28 US disclosed
EP-2064959-B1 Aromatic Neomenthylamides as flavouring agents SYMRISE AG (DE) 2012-07-25 EP disclosed
EP-2064959-A1 Aromatic Neomenthylamides as flavouring agents Symrise GmbH & Co. KG (DE) 2009-06-03 EP disclosed
US-20090110796-A1 AROMATIC NEOMENTHYLAMIDES AS FLAVORING SUBSTANCES SYMRISE GMBH & CO. KG (DE) 2009-04-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090110796-A1 AROMATIC NEOMENTHYLAMIDES AS FLAVORING SUBSTANCES AOC3, NPR3, AOC2 TRPV1 716/4885TRPM8 1514/4885CYP2D6 1006/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.