SCHEMBL4083823

SCHEMBL4083823

CCNC(=O)c1cc(N)cc(C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CARM1 Q86X55 5/20 0.37
KLKB1 P03952 4/20 0.36
KDM4E B2RXH2 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CHIA Q9BZP6 1/20 0.35
STIM1 Q13586 1/20 0.35
ORAI1 Q96D31 1/20 0.35
F10 P00742 3/20 0.35
F2 P00734 2/20 0.35
PDE4B Q07343 1/20 0.35
GRIN1 Q05586 1/20 0.34
GRIN2A Q12879 1/20 0.34
NTRK1 P04629 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14360671 0.92 KLKB1 (0.37) CARM1KLKB1KDM4ECHIASTIM1
SCHEMBL4082479 0.91 CARM1 (0.40) CARM1KLKB1KDM4EL3MBTL1STIM1
SCHEMBL10028766 0.90 CARM1 (0.35) CARM1KLKB1KDM4ECHIASTIM1
SCHEMBL10028757 0.90 DHODH (0.36) CARM1KLKB1KDM4ECHIASTIM1
SCHEMBL2935274 0.89 CARM1 (0.36) CARM1KLKB1KDM4EL3MBTL1F10
SCHEMBL10028754 0.87 NTRK1 (0.37) CARM1KLKB1KDM4ECHIASTIM1
SCHEMBL13318521 0.85 JAK2 (0.35) CARM1KLKB1STIM1ORAI1PDE4B
SCHEMBL949725 0.85 KLKB1 (0.38) CARM1KLKB1KDM4EL3MBTL1STIM1
SCHEMBL951313 0.85 KLKB1 (0.38) CARM1KLKB1KDM4EF10F2
SCHEMBL10028770 0.85 CHIA (0.38) CARM1KLKB1KDM4ECHIASTIM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8658801-B2 Pesticides containing a bicyclic bisamide structure SYNGENTA CROP PROTECTION, LLC (US) 2014-02-25 US disclosed
US-20090298816-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA CROP PROTECTION, INC. (US) 2009-12-03 US disclosed
EP-1984354-B1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA PARTICIPATIONS AG (CH) 2009-08-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090298816-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE DDT, ACHE, GAP43 CARM1 669/4885KLKB1 4802/4885KDM4E 2264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.