SCHEMBL4082479

SCHEMBL4082479

CNC(=O)c1cc(N)cc(C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.64

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CARM1 Q86X55 2/20 0.40
KDM4E B2RXH2 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
PDE4B Q07343 2/20 0.36
F10 P00742 5/20 0.36
F2 P00734 3/20 0.36
KLKB1 P03952 2/20 0.36
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
LMNA P02545 1/20 0.35
POLB P06746 1/20 0.35
TRPV1 Q8NER1 1/20 0.35
STIM1 Q13586 1/20 0.34
ORAI1 Q96D31 1/20 0.34
F9 P00740 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12911856 0.91 CARM1 (0.39) CARM1KDM4EPDE4BKLKB1MEN1
SCHEMBL25702787 0.91 TRPV1 (0.39) CARM1KDM4EPDE4BF10F2
SCHEMBL782368 0.91 CARM1 (0.39) CARM1KDM4EPDE4BF10KLKB1
SCHEMBL4083823 0.91 CARM1 (0.37) CARM1KDM4EL3MBTL1PDE4BF10
SCHEMBL2935274 0.91 CARM1 (0.36) CARM1KDM4EL3MBTL1PDE4BF10
SCHEMBL14434285 0.91 CARM1 (0.39) CARM1KDM4EPDE4BF10KLKB1
SCHEMBL782214 0.90 CARM1 (0.38) CARM1KDM4EPDE4BF10F2
SCHEMBL958266 0.90 CARM1 (0.38) CARM1KDM4EPDE4BF10KLKB1
SCHEMBL12911821 0.89 CARM1 (0.41) CARM1KDM4EPDE4BF10KLKB1
SCHEMBL14405305 0.89 DHODH (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8658801-B2 Pesticides containing a bicyclic bisamide structure SYNGENTA CROP PROTECTION, LLC (US) 2014-02-25 US disclosed
EP-2213167-A1 Anthranilamide derivatives and their use for the control of insects and acari Syngenta Participations AG (CH) 2010-08-04 EP disclosed
US-20090298816-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA CROP PROTECTION, INC. (US) 2009-12-03 US disclosed
EP-1984354-B1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA PARTICIPATIONS AG (CH) 2009-08-05 EP disclosed
EP-1984354-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE Syngeta Participations AG (CH) 2008-10-29 EP disclosed
WO-2007093402-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA PARTICIPATIONS AG (CH) 2007-08-23 WO disclosed
WO-2007093402-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA PARTICIPATIONS AG (CH) 2007-08-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090298816-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE DDT, ACHE, GAP43 CARM1 669/4885KDM4E 2264/4885L3MBTL1 1867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.