Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 8/20 | 0.57 |
| ▸ | FLT3 | P36888 | 7/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.44 |
| ▸ | GSK3B | P49841 | 7/20 | 0.44 |
| ▸ | CLK2 | P49760 | 3/20 | 0.44 |
| ▸ | CLK3 | P49761 | 3/20 | 0.44 |
| ▸ | WNT1 | P04628 | 2/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081942 | 0.87 | KIT (0.54) | KITFLT3DYRK1AGSK3BCLK2 | |
| SCHEMBL3881539 | 0.83 | AURKA (0.60) | KITFLT3INSRIGF1RALK | |
| SCHEMBL4088594 | 0.82 | GPR35 (0.55) | — | |
| SCHEMBL4088196 | 0.82 | KDR (0.54) | KITFLT3INSRIGF1RALK | |
| SCHEMBL3883058 | 0.81 | AURKA (0.59) | KITFLT3 | |
| SCHEMBL4081022 | 0.79 | FLT3 (0.50) | KITFLT3 | |
| SCHEMBL2431632 | 0.79 | KIT (0.57) | KITFLT3DYRK1AGSK3BCLK2 | |
| SCHEMBL4089596 | 0.79 | FLT3 (0.49) | KITFLT3ALK | |
| SCHEMBL4082126 | 0.77 | HDAC6 (0.48) | GSK3B | |
| SCHEMBL24244969 | 0.77 | KIT (0.66) | KITFLT3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |