Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 6/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 4/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078156 | 0.92 | KDR (0.45) | KDRHDAC6FLT3KITAURKA | |
| SCHEMBL4082914 | 0.92 | HRH3 (0.48) | KDRHDAC6FLT3KITAURKA | |
| SCHEMBL4088588 | 0.91 | HRH3 (0.49) | KDRHDAC6FLT3KITAURKA | |
| SCHEMBL4083450 | 0.90 | HIF1A (0.54) | FLT3AURKAHDAC1 | |
| SCHEMBL3881539 | 0.87 | AURKA (0.60) | FLT3KITAURKAALKNTRK1 | |
| SCHEMBL4081436 | 0.86 | AURKA (0.57) | KDRHDAC6FLT3KITBTK | |
| SCHEMBL4093460 | 0.82 | AURKA (0.48) | KDRHDAC6FLT3KITBTK | |
| SCHEMBL4084078 | 0.82 | KIT (0.57) | FLT3KITALKINSRIGF1R | |
| SCHEMBL4092896 | 0.81 | HDAC6 (0.51) | HDAC6FLT3 | |
| SCHEMBL2914525 | 0.80 | AURKA (0.57) | FLT3KITAURKAF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |