Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.49 |
| ▸ | KDR | P35968 | 8/20 | 0.49 |
| ▸ | FLT1 | P17948 | 5/20 | 0.49 |
| ▸ | KIT | P10721 | 4/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 4/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082984 | 0.86 | AURKA (0.48) | FLT3KDRFLT1KITMCHR1 | |
| SCHEMBL4082914 | 0.85 | HRH3 (0.48) | FLT3KDRKITAURKAKDM4E | |
| SCHEMBL4088588 | 0.84 | HRH3 (0.49) | FLT3KDRKITAURKAKDM4E | |
| SCHEMBL4078156 | 0.83 | KDR (0.45) | FLT3KDRKITAURKAKDM4E | |
| SCHEMBL4081802 | 0.83 | FLT3 (0.43) | FLT3KDRFLT1KITMCHR1 | |
| SCHEMBL4088196 | 0.79 | KDR (0.54) | FLT3KDRFLT1KITAURKA | |
| SCHEMBL4088594 | 0.79 | GPR35 (0.55) | AURKACCNA2CDK2CCNA1 | |
| SCHEMBL4084078 | 0.79 | KIT (0.57) | FLT3KITALK | |
| SCHEMBL4081022 | 0.78 | FLT3 (0.50) | FLT3KIT | |
| SCHEMBL4083450 | 0.77 | HIF1A (0.54) | FLT3AURKACDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |