Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | CCR2 | P41597 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL208749 | 0.92 | CCR2 (0.45) | OPRM1OPRL1CCR2KCNH2 | |
| SCHEMBL207647 | 0.83 | KDM4E (0.46) | KMT2A | |
| SCHEMBL206307 | 0.81 | OPRM1 (0.52) | OPRM1OPRL1CCR2KCNH2 | |
| SCHEMBL5158003 | 0.79 | CHRM4 (0.42) | OPRM1OPRL1CCR2KCNH2 | |
| SCHEMBL206822 | 0.78 | OPRM1 (0.47) | OPRM1OPRL1KMT2A | |
| SCHEMBL206118 | 0.77 | HDAC3 (0.45) | OPRM1OPRL1CCR2KCNH2 | |
| SCHEMBL206198 | 0.76 | ALDH1A1 (0.45) | KMT2A | |
| SCHEMBL4074077 | 0.76 | OPRM1 (0.51) | OPRM1OPRL1EPHX2 | |
| SCHEMBL206119 | 0.75 | OPRM1 (0.43) | OPRM1OPRL1CCR2KCNH2DRD2 | |
| SCHEMBL208760 | 0.74 | SMYD3 (0.48) | OPRM1OPRL1CCR2KCNH2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745010-B1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | claimed |